A Promising Celiac Disease Drug is Moving into Phase II Clinical Trial

Become Gluten Free – The Secrets to Living Healthy

ImmusanT, a biotechnology company focusing on protecting patients with celiac disease against the effects of gluten, has announced that it has secured $40 million in funding to advance its drug, Nexvax2®, into a Phase II clinical trial. Nexvax2 is a therapeutic vaccine designed to stimulate immune tolerance in patients with celiac disease.

Nexvax2® is the sole therapeutic approach for celiac disease in clinical development today that aims to mitigate the loss of immune tolerance to gluten. If successful, it intends to protect patients with celiac disease against unintentional gluten exposure. ImmusanT was a proud sponsor of the 2017 Celiac Disease Foundation (CDF) Patients as Partners Research Symposium. CDF looks forward to continuing our collaboration through to the final approval of the drug by the FDA and its release to market.

ImmusanT Raises $40 Million in Series C Financing

— ARCH Venture Partners joins Vatera Healthcare Partners as Equity Investor —
— Proceeds Will Support Phase II Study of Nexvax2®, ImmusanT’s
Immunotherapy and Diagnostic for Celiac Disease —
— Steven Gillis, Ph.D., and Thomas Daniel, M.D. join Board of Directors —

CAMBRIDGE, Mass. – November 14, 2017 – ImmusanT, Inc., a clinical-stage company developing Nexvax2®, a therapeutic vaccine designed to induce immune tolerance in celiac disease, today announced the completion of a $40 million Series C equity financing from ARCH Venture Partners and Vatera Healthcare Partners. The proceeds will fund a randomized Phase II clinical trial of escalating doses of Nexvax2 in celiac patients who possess the human leukocyte antigen-DQ2.5 (HLA-DQ2.5) immune recognition gene. Nexvax2 will be studied as an adjunct to a gluten-free diet to demonstrate clinically relevant proof of concept for patients receiving a gluten challenge. Funds will also be used for the continued advancement of the company’s diagnostic biomarker program and platform expansion.

ARCH Venture Partners, who led the Series C financing, joins Vatera Healthcare Partners as an equity investor in the company. Steven Gillis, Ph.D., Managing Director, and Thomas O. Daniel, M.D., Venture Partner of ARCH Venture Partners, will join ImmusanT’s Board of Directors. Dr. Gillis is a trained immunologist and is credited with pioneering the field of cytokines and cytokine receptors. Dr. Daniel is the former President and Chairman of Research and Early Development at Celgene Corporation.

“ARCH’s support and the addition of Drs. Gillis and Daniel to our Board of Directors represents a significant inflection point for our company,” said Leslie Williams, President and Chief Executive Officer of ImmusanT. “With this investment, we are well-positioned to advance Nexvax2 in the clinic and advance the biomarker program. In addition, we are looking forward to exploiting the potential of our Epitope-Specific Immuno-Therapy (ESIT) platform to develop new therapies that could benefit patients beyond those living with celiac disease.”

Approximately 90% of celiac disease patients carry the HLA-DQ2.5 immune recognition gene, the target of Nexvax2. Currently, there is no FDA-approved therapeutic for the treatment of celiac disease. Approximately 30% of adults with celiac disease have other autoimmune diseases such as type 1 diabetes and thyroid disease.

“ARCH’s investment reflects the potential of Nexvax2 to induce antigen-specific tolerance for the treatment of celiac disease, and the potential of ImmusanT’s broader platform to treat a range of autoimmune diseases including type 1 diabetes,” said Dr. Gillis. “ImmusanT has effectively positioned itself as a leader in the development of antigen-specific immunotherapies, and we look forward to working with the ImmusanT team to advance Nexvax2 and the platform, and ultimately help patients.”

“We are pleased to welcome ARCH to the ImmusanT investor base, and Drs. Gillis and Daniel, who bring a combination of unparalleled immunology knowledge and exceptional research and business accomplishments to the Board of Directors,” said Kevin Ferro, Chairman of the Board of ImmusanT and Co-founder of Vatera Healthcare Partners. “We look forward to their contributions and insights as ImmusanT advances the development of our novel vaccine programs in celiac disease and other potential indications.”

To learn more about Dr. Gillis, Dr. Daniel and the ImmusanT Board of Directors please visit www.ImmusanT.com/board.
MTS Health Partners, L.P. advised on the transaction.

About Nexvax2®
Nexvax2® is the only therapeutic approach for celiac disease in clinical development today that targets the fundamental cause of the disease; the loss of immune tolerance to gluten. Nexvax2® is a therapeutic vaccine that reprograms the T-cells responsible for the symptoms of celiac disease to stop triggering a pro-inflammatory response. Nexvax2® intends to protect patients with celiac disease against inadvertent exposure to gluten.

About ImmusanT, Inc.
ImmusanT is a privately held biotechnology company focused on protecting patients with celiac disease against the effects of gluten. By harnessing new discoveries in immunology, ImmusanT aims to improve diagnosis and medical management of celiac disease by protecting against the effects of gluten exposure while patients maintain a gluten-free diet. The company is developing Nexvax2®, a therapeutic vaccine for celiac disease, and diagnostic and monitoring tools to improve celiac disease management. ImmusanT’s targeted immunotherapy discovery platform can be applied to a variety of autoimmune diseases. To learn more about ImmusanT, visit www.ImmusanT.com, or follow ImmusanT on Twitter.

About ARCH Venture Partners
ARCH Venture Partners, one of the largest early stage technology venture firms in the U.S., invests in seed and early stage advanced technology companies. ARCH enjoys special recognition as a leader in the commercialization of technologies developed at academic institutions, corporate research labs and national laboratories. ARCH has earned a reputation as one of the leading venture firms in early stage biotechnology, advanced materials, alternative energy, and specialty semiconductors, and is known for identifying and capitalizing early on fundamental trends in disruptive technology. Now in its 30th year, ARCH has over $2 billion in committed capital through nine venture funds, and has co-founded and provided initial investments for over 200 companies, including Illumina, Juno Therapeutics, Receptos, Kythera Biopharmaceuticals, Ikaria and Agios Pharmaceuticals. http://www.archventure.com/

About Vatera Healthcare Partners LLC
Vatera Healthcare Partners is a venture and private equity firm focused on investing in companies and products across the healthcare spectrum, with a particular focus in the life sciences, with the goal of identifying and developing best-in-class therapies to treat unmet medical needs and improve patients’ lives. Vatera Healthcare Partners aims to pursue this objective by utilizing its team’s deep industry expertise to identify and help create leading companies with differentiated assets and/or business models across stages of development and commercialization with the potential to generate meaningful value over time. http://vaterahealthcare.com/

ImmusanT Contact:
Leslie Williams
President and CEO
(617) 299-8399 Ext. 201
Leslie@ImmusanT.com

Media Contact:
George E. MacDougall
MacDougall Biomedical Communications
(781) 235-3093
george@macbiocom.com

View the original press release here.

A Promising Celiac Disease Drug is Moving into Phase II Clinical Trial

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Natural Breast Cancer Treatment: How to Beat Breast Cancer

Being 100% Gluten Free – The Secrets to Living Healthy

Natural Breast Cancer Treatment: How to Beat Breast Cancer
Learn more about cancer-fighting foods on my website here: https://draxe.com/cancer-fighting-foods/?utm_campaign=Live-Nov-2017&utm_medium=social&utm_source=youtube&utm_term=breastcancertreatment

It’s the sentence straight out of every woman’s worst nightmare: “You have breast cancer.” About 1 in 8 women in the United States (about 12 percent) will develop invasive breast cancer over the course of her lifetime. For most, the recommended course of action will be a lumpectomy. Some will undergo radiation as well. Others have a mastectomy — or a double mastectomy.

The smallest portion will try natural breast cancer treatment options. Natural breast cancer treatment involves eating inflammation-lowering foods and supplementing with essential nutrients. Watch to learn more about how to beat breast cancer naturally.

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*This content is strictly the opinion of Dr. Josh Axe, and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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BurstFIT At Home | Cardio Workout

Being 100% Gluten Free – The Secrets to Living Healthy

BurstFIT At Home | Cardio Workout
Find out more about cardio workouts on DrAxe.com here: https://draxe.com/cardio-workouts/?utm_campaign=Workout-Nov-2017&utm_medium=social&utm_source=youtube&utm_term=burstfitathomecardio

Can’t make it to the gym? Looking for an awesome cardio workout to help jumpstart your metabolism and increase your fat burning potential? This at-home cardio workout routine, presented by Dr. Chelsea Axe, will help burn fat without the need for a gym membership or any equipment.

Burst training is said to burn up to 3x more body fat than moderate cardio, allow your body to keep burning fat for 48 hours after you’re done exercising and require less time than traditional cardio. Get started today to see for yourself.

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Subscribe to my channel for more workout information!!

Facebook: https://www.facebook.com/Burstfit/
Instagram: https://www.instagram.com/burst_fit/

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*DrAxe.com strongly recommends that you consult with your physician before beginning any exercise program. You should be in good physical condition and be able to participate in the exercise. You should understand that when participating in any exercise or exercise program, there is the possibility of physical injury. If you participate in this exercise or exercise program, you agree that you do so at your own risk, are voluntarily participating in these activities, assume all risk of injury to yourself, and agree to release and discharge DrAxe.com from any and all claims or causes of action, known or unknown, arising out of DrAxe.com's negligence.

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Gluten-Free Sweet Potato Pie Recipe

Being 100% Gluten Free – The Secrets to Living Healthy

Gluten-Free Sweet Potato Pie Recipe
Find the full recipe for this sweet potato pie on my website here: https://draxe.com/recipe/gluten-free-sweet-potato-pie-recipe/?utm_campaign=Recipe-Nov-2017&utm_medium=social&utm_source=youtube&utm_term=sweetpotatopie

Have you tried homemade sweet potato pie before? If not, you’re really in for a treat. Sweet potato pie, like pumpkin pie, tends to pop up on dinner tables around the holidays, especially Thanksgiving, but it’s really a dessert that can be enjoyed any time of the year. Watch to learn how to make this sweet potato pie recipe and click on the link for details.

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Dr. Axe is on a mission to transform the health of millions all across America with the belief that Food is Medicine. Dr. Josh Axe is a certified nutrition specialist, a natural medicine expert, a licensed chiropractor and specializes in functional medicine.

Subscribe to my channel for more healthy, delicious recipes!

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Want more? Sign up to get the Dr. Axe Food Is Medicine e-newsletter, sent out a few times a week: https://draxe.com/subscribe-to-newsletter/

*This content is strictly the opinion of Dr. Josh Axe, and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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SPONSORED POST: Schär’s Power Toast

Being Gluten Free – The Secrets to Living Healthy

Are you already wondering how you’ll manage this season’s endless list of shopping sprees, holiday parties, and family gatherings? Not to worry, we have you covered. Schär’s energizing power toast recipes—all made on their healthy Artisan Baker 10 Grains & Seeds loaf—will give you all the energy you need this holiday season.

RECIPES

Ingredients:

6 slices Artisan Baker 10 Grains & Seeds bread

For the Hummus and Tomato Toast:

2 tbsp. of hummus

2 thin slices of tomato

1 pinch of radish sprouts

1 pinch of crushed red chili flakes

For the Avocado and Radish Toast:

1 small, smashed and ripe avocado

2 small, sliced radishes

1 pinch of salt

1 pinch of crushed red chili flakes

A little bit of olive oil

For the Kiwi and Walnut Toast:

2 small, sliced kiwis

2 tbsp. of Greek yogurt

1 small handful of coarsely chopped walnuts

For the Banana and Cherry Toast:

1 tbsp. of almond butter

7 slices of banana

1 small handful of roughly chopped, dried cherries

1 pinch of sunflower seeds

A little bit of honey

For the Cucumber and Smoked Salmon Toast:

1½ tbsp. of cream cheese

6 slices of cucumber

2 slices of smoked salmon

A pinch of sesame seeds

A pinch of sprouts

For the Mango and Almond Toast:

1 tbsp. of Greek yogurt

4 slices of fresh mango

1 pinch of slivered almonds

1 small handful of coconut flakes

Preparation

Toast all 6 slices of toast

Preparation of the Hummus and Tomato Toast:

Spread the hummus on one piece of toast. Layer the slices of tomato, followed by a pinch of sprouts. Top with the sprinkle of chili flakes.

Preparation of the Avocado and Radish Toast:

Top a slice of toast with smashed avocado and then layer on the radish slices. Sprinkle a pinch of sea salt and red chili flakes over the top. Finish with a drizzle of olive oil.

Preparation of Kiwi and Walnut Toast:

Layer a piece of toast with slices of kiwi and a dollop of Greek yogurt. Top it off with the finely crushed walnuts.

Preparation of the Banana and Cherry Toast:

Spread almond butter over a piece of toast. Layer on sliced banana and a handful of dried cherries. Then, scatter the sunflower seeds over the top and end with a drizzle of honey.

Preparation of the Cucumber and Smoked Salmon Toast:

Cover a slice of toast with cream cheese. Then layer on the cucumber slices and slices of salmon. Top it off with sprouts and a sprinkle of sesame seeds.

Preparation of the Mango and Almond Toast:

Spread the Greek yogurt over the slice of toast. Then, layer the mango slices on top and cover with almond slivers and coconut chips.

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Orange Spice Cranberry Sauce

Being Gluten Free – The Secrets to Living Healthy

By Jilly Lagasse

This Orange Spice Cranberry Sauce will absolutely be the easiest thing you make all holiday season! This sauce is just the right balance of tangy, tart and sweet to serve with your holiday bird or pork or even on some roasted veggies. It’s also fantastic smeared onto some gluten-free bread for your day-after sandwiches. This dish is gluten free, vegan and nut free.

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BurstFIT At Home | Core & Ab Workout

Being 100% Gluten Free – The Secrets to Living Healthy

BurstFIT At Home | Core & Ab Workout
Find more ab workouts on DrAxe.com here: https://draxe.com/ab-workouts/?utm_campaign=Workout-Nov-2017&utm_medium=social&utm_source=youtube&utm_term=burstfitathomecore

Can’t make it to the gym? Looking for an ab workout? This at-home ab workout routine, presented by Dr. Chelsea Axe, will help burn fat and sculpt your abs — without the need for a gym membership or any equipment.

Burst training is said to burn up to 3x more body fat than moderate cardio, allow your body to keep burning fat for 48 hours after you’re done exercising and require less time than traditional cardio. Get started today to see for yourself.

—————————————————————
Subscribe to my channel for more workout information!!

Facebook: https://www.facebook.com/Burstfit/
Instagram: https://www.instagram.com/burst_fit/

—————————————————————
Want more? Sign up to get the Dr. Axe Food Is Medicine e-newsletter, sent out a few times a week: https://draxe.com/subscribe-to-newsletter/

*DrAxe.com strongly recommends that you consult with your physician before beginning any exercise program. You should be in good physical condition and be able to participate in the exercise. You should understand that when participating in any exercise or exercise program, there is the possibility of physical injury. If you participate in this exercise or exercise program, you agree that you do so at your own risk, are voluntarily participating in these activities, assume all risk of injury to yourself, and agree to release and discharge DrAxe.com from any and all claims or causes of action, known or unknown, arising out of DrAxe.com's negligence.

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Carb Cycling vs. Keto Diet vs. Paleo Diet

Being 100% Gluten Free – The Secrets to Living Healthy

Carb Cycling vs. Keto Diet vs. Paleo Diet
Learn more about a carb cycling diet on my website here: https://draxe.com/carb-cycling-diet/?utm_campaign=Live-Nov-2017&utm_medium=social&utm_source=youtube&utm_term=carbcycling

There are a lot of diet plans out there. There is the carb cycling diet, keto diet (or ketogenic diet), Paleo diet, vegan diet and vegetarian diet … And that's not even all of them. It can get complicated and confusing to understand which diet might be the best option for you and your health goals.

Today, my wife, Dr. Chelsea Axe, and I are going over what a carb cycling diet is, what a keto diet is and what a Paleo diet is. Whether you’re looking to balance hormones or boost your metabolism, there is a diet out there for you. Watch to learn more.

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Want more? Sign up to get the Dr. Axe Food Is Medicine e-newsletter, sent out a few times a week: https://draxe.com/subscribe-to-newsletter/

*This content is strictly the opinion of Dr. Josh Axe, and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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